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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9911 | Tocilizumab | Interleukin | |
Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor | |||
T76978 | Siltuximab | CNTO-328 | IL Receptor |
Siltuximab(CNTO-328) is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19. | |||
T0097 | MRT67307 | MRT67307 HCl | IκB/IKK , Autophagy |
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage... | |||
T77174 | Efmarodocokin alfa | ||
Efmarodocokin alfa, a fusion protein combining human IL-22 with the IgG4 crystallizable fragment, activates IL-22 signaling. This compound has potential applications in the study of severe COVID-19 pneumonia [1]. | |||
T73372 | GNE-2256 | ||
GNE-2256, also known as molecule 19, is an orally active compound that inhibits Interleukin 1 receptor-associated kinase 4 (IRAK4) with a K i of 1.4 nM and has an IL-6 inhibition concentration (IC50) of 190 nM. | |||
T78175 | JAK-IN-25 | JAK | |
JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-1... | |||
T36534 | SDZ 224-015 | SDZ 224015 | IL Receptor , Caspase |
SDZ 224-015 is an orally active inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1.SDZ 224-015 exhibits anti-COVID-19 and anti-inflammatory activity, and reduces carrageenan gum-induced paw edema in rats... | |||
T36885 | BMSpep-57 hydrochloride | ||
BMSpep-57 hydrochloride, a potent macrocyclic peptide, competitively inhibits PD-1/PD-L1 interaction, exhibiting an IC50 value of 7.68 nM. It binds to PD-L1 with dissociation constants (Kds) of 19 nM and 19.88 nM as dete... | |||
T76675 | Clazakizumab | ||
Clazakizumab, a monoclonal antibody, demonstrates high affinity and specificity towards the interleukin-6 (IL-6) cytokine, potentially inhibiting the cytokine response in COVID-19 caused by SARS-CoV-2. It is also under r... | |||
T35468 | (±)19(20)-EDP Ethanolamide | ||
(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively). It is produced through direct epoxygenation of docosahexaenoyl et... | |||
T39106 | BMSpep-57 | ||
BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1/PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 wit... | |||
T79449 | Antileishmanial agent-19 | Parasite | |
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and d... | |||
T23028 | MRT67307 HCl (1190378-57-4 free base) | MRT67307 HCl | Others |
MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it i... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40660 | Kansuinine B | IL Receptor , SARS-CoV | |
Kansuinine B inhibits Stat3 activation induced by IL-6. Kansuinine B exhibits anti-viral activity and could be used in COVID-19 research. | |||
TN1154 | Nepetin | 6-Methoxyluteolin | Calcium Channel , Histamine Receptor |
Nepetin (6-Methoxyluteolin) has antioxidant activity, it is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain. |
Cat No. | Product Name | Species | Expression System |
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TMPK-01229 | IL-19 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating... | |||
TMPY-00493 | IL-19 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the r... | |||
TMPY-00406 | IL-23 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1. | |||
TMPY-05247 | IL-23 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
IL-23 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1. | |||
TMPY-05648 | IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.6 kDa and the accession number is NP_002178.2&NP_057668.1. | |||
TMPY-04874 | IL-23 P19/IL23A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7. | |||
TMPY-00841 | IL-13RA2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-13RA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627. | |||
TMPY-04987 | IL-23 P19/IL23A Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7. | |||
TMPK-01169 | IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells... | |||
TMPK-00273 | IL-13Ra1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,... | |||
TMPK-00272 | IL-13RA1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha,... | |||
TMPY-05334 | IL-13RA2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells |
IL-13RA2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q14627. | |||
TMPY-00842 | IL-13RA2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
IL-13RA2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 65 kDa and the accession number is Q14627. | |||
TMPJ-00244 | IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated | Human | HEK293 Cells |
IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 80-100 KDa and the accession number is P26951... | |||
TMPK-00242 | IL-3R alpha/CD123 Protein, Human, Recombinant (aa 19-305, His & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 sub... | |||
TMPY-00846 | IL-18BP Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2. | |||
TMPJ-00161 | IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated | Human | E. coli |
IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated is expressed in E. coli expression system with C-Avi tag. The predicted molecular weight is 19 KDa and the accession number is P01583. | |||
TMPJ-00078 | IL-17C Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-17C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is Q9P0M4. | |||
TMPJ-00633 | IL-17F Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
IL-17F Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19-22 KDa and the accession number is G7P4V0. | |||
TMPJ-00573 | IL-17F Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-17F Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is AAH70124.1. | |||
TMPJ-00909 | IL-1RA Protein, Mouse, Recombinant | Mouse | E. coli |
Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and int... |